On Wednesday, February 3, 2016 the Psychopharmacologic Drugs Advisory Committee (PDAC) considered the clinical presentation and assessment of cognitive dysfunction in major depression (MDD). The Committee supported, by a vote of 8-Yes to 2-No, with no abstentions, a new claim for the treatment of cognitive dysfunction in MDD for Brintellix (vortioxetine), based on the data that was submitted in a supplemental New Drug Application (sNDA) by Takeda Development Center Americas, Inc. (Takeda).